Exploring New Evidence: Non-Botulinum Toxin Injections for Headache Relief

At Southeast Center for Headaches, we believe staying ahead of the latest research is essential to delivering the best possible care. That’s why we’re excited to highlight a recent article published in Practical Neurology (May–June 2025 issue), which reviews the growing evidence behind non-botulinum toxin injections as a promising option for patients living with chronic headaches.

What Are Non-Botulinum Toxin Injections?

These are injectable treatments that target specific nerve or muscle pain pathways—without using botulinum toxin (such as Botox®). They include agents like local anesthetics and corticosteroids, and they’re being explored as safer, cost-effective alternatives for certain types of headache sufferers.

What the Research Says

The article reviews current clinical evidence supporting the use of these injections in the treatment of chronic migraine, cluster headache, and other difficult-to-manage headache disorders. While further research is ongoing, many patients are already experiencing meaningful relief using these options.

Why It Matters

For patients who:

• Haven’t responded to oral medications,

• Are not ideal candidates for botulinum toxin therapy,

• Or are seeking alternatives to daily drug regimens—

These injections may offer targeted relief with fewer side effects.

Read the Full Article

You can explore the full article from Practical Neurology here:

👉 Read the article

Interested in learning if this treatment might be right for you?

📞 Contact us today to schedule a consultation with one of our headache specialists.